Andy Otten joined the Adelaide Crows in 2007, when they picked him with the 27th selection in the National Draft. At 192cm, Otten has primarily played in defence; however it is not uncommon for him to play in the ruck or as a key forward when the need arises. As a result, he is regarded for his team first attitude.
After debuting in 2008, Otten played every game in 2009 as a running defender, and finished Runner-Up in the AFL Rising Star Award. Only months later, Otten suffered his first ACL injury which kept him out for the season, then ruptured his other ACL in 2014. On the second occasion, he returned to the senior side 960 days later.
Throughout 2015 and 2016 Otten spent a lot of time around the SANFL side, and took on a leadership role in a team which is primarily developing. The 2017 season saw Otten return to the AFL side mainly playing as a ruck right through to the Grand Final, and in 2018 he reached his well deserved 100th game milestone and Life Membership.